The GTP-binding Proteins as Targets for Bacterial Toxins.
نویسندگان
چکیده
منابع مشابه
Small GTP-binding proteins.
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families. They regulate a wide variety of cell functions as biological timers (biotimers) that initiate and terminate specific cell functions...
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Rheb proteins represent a novel and unique family of the Ras superfamily GTP-binding proteins that is conserved from yeast to human. Biochemical studies establish that they bind and hydrolyze GTP. Molecular modeling studies reveal a few structural differences between Rheb and Ras, which may suggest that residues involved in biochemical activities differ between the two G-proteins. The function ...
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Ras oncogenes are the most commonly known oncogenes in human tumors; their prevalence in different types of tumors and their role in the development of these tumors have been discussed in recent reviews (1,2). We have investigated the biochemical mechanism that accounts for the activation of ras proto-oncogenes to become oncogenes. In normal cells, the ras p21 cycles between the active guanosin...
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Autophagy is a physiological process involved in defense mechanisms for clearing intracellular bacteria. The autophagic pathway is finely regulated and bacterial toxins interact with this process in a complex manner. Bacterial toxins also interact significantly with many biochemical processes. Evaluations of the effects of bacterial toxins, such as endotoxins, pore-forming toxins and adenylate ...
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Glucose-stimulated insulin secretion [GSIS] involves interplay between small G-proteins and their regulatory factors. Herein, we tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide-exchange factor [GEF] for the small G-protein Arf6, mediates the functional activation of Arf6, and that ARNO/Arf6 signaling axis, in turn, controls the activation of Cdc42 and ...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1997
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.52.727